Drug interactions
Amlodipine-benazepril + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Amlodipine-benazepril and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel-preparation salts can cause fluid loss and electrolyte shifts, including raised magnesium. Combined with a calcium channel blocker and an ACE inhibitor, this may add to hypotension, muscle weakness and renal impairment.
What this interaction means in plain words
Amlodipine-benazepril and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory effects of magnesium and calcium channel blockade, plus volume depletion and electrolyte disturbance that raise ACE inhibitor-related renal risk.
What to do
Ensure adequate hydration during bowel preparation and consider holding the ACE inhibitor on the day of preparation in volume-depleted or high-risk patients. Monitor blood pressure, renal function and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel-preparation salts can cause fluid loss and electrolyte shifts, including raised magnesium. Combined with a calcium channel blocker and an ACE inhibitor, this may add to hypotension, muscle weakness and renal impairment.
How serious is the interaction between Amlodipine-benazepril and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration during bowel preparation and consider holding the ACE inhibitor on the day of preparation in volume-depleted or high-risk patients. Monitor blood pressure, renal function and electrolytes.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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