Drug interactions
Amlodipine-benazepril + Xipamide
Severity: Moderate
Amlodipine-benazepril and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic that adds to the blood pressure lowering effect of amlodipine and benazepril. This is often intended but can cause excessive hypotension, volume depletion or electrolyte disturbance.
What this interaction means in plain words
Amlodipine-benazepril and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects from diuresis and vasodilation.
What to do
Monitor blood pressure, renal function and electrolytes after starting or changing doses. Consider starting the diuretic at a low dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Frequently asked questions
Can I take Amlodipine-benazepril with Xipamide?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic that adds to the blood pressure lowering effect of amlodipine and benazepril. This is often intended but can cause excessive hypotension, volume depletion or electrolyte disturbance.
How serious is the interaction between Amlodipine-benazepril and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or changing doses. Consider starting the diuretic at a low dose.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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