Drug interactions
Amlodipine-olmesartan + Asenapine
Severity: Moderate
Amlodipine-olmesartan and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension through alpha-1 adrenergic blockade. Concurrent antihypertensives may enhance this effect, raising the risk of dizziness, syncope and falls.
What this interaction means in plain words
Amlodipine-olmesartan and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Asenapine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from asenapine alpha-adrenergic antagonism and the vasodilating actions of amlodipine and olmesartan.
What to do
Monitor orthostatic blood pressure when starting or increasing asenapine, especially in older patients. Reduce antihypertensive doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Asenapine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension through alpha-1 adrenergic blockade. Concurrent antihypertensives may enhance this effect, raising the risk of dizziness, syncope and falls.
How serious is the interaction between Amlodipine-olmesartan and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or increasing asenapine, especially in older patients. Reduce antihypertensive doses if symptomatic hypotension develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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