Drug interactions
Amlodipine-olmesartan + Axitinib
Severity: Minor
Amlodipine-olmesartan and Axitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is only a weak CYP3A4 inhibitor, so any rise in axitinib exposure is likely small. Axitinib itself commonly raises blood pressure, which may be relevant when antihypertensives are being titrated.
What this interaction means in plain words
Amlodipine-olmesartan and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Axitinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated axitinib metabolism by amlodipine.
What to do
No dose change is usually needed; monitor blood pressure and axitinib adverse effects such as hypertension and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Axitinib?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is only a weak CYP3A4 inhibitor, so any rise in axitinib exposure is likely small. Axitinib itself commonly raises blood pressure, which may be relevant when antihypertensives are being titrated.
How serious is the interaction between Amlodipine-olmesartan and Axitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood pressure and axitinib adverse effects such as hypertension and diarrhea.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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