Drug interactions
Apalutamide + Axitinib
Severity: Major
Apalutamide and Axitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide, a strong CYP3A4 inducer, can markedly reduce axitinib exposure and compromise anticancer efficacy.
What this interaction means in plain words
Apalutamide and Axitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Axitinib belongs to Oncology.
Why it happens
Induction of CYP3A4/5 increases axitinib metabolism.
What to do
Avoid strong CYP3A4 inducers with axitinib and choose an alternative. If unavoidable, monitor efficacy closely and adjust the axitinib dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
- Axitinib + Conivaptan Major
Frequently asked questions
Can I take Apalutamide with Axitinib?
MediHelp rates the interaction as major. Apalutamide and Axitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide, a strong CYP3A4 inducer, can markedly reduce axitinib exposure and compromise anticancer efficacy.
How serious is the interaction between Apalutamide and Axitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inducers with axitinib and choose an alternative. If unavoidable, monitor efficacy closely and adjust the axitinib dose per labeling.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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