Drug interactions
Amlodipine-olmesartan + Drospirenone
Severity: Moderate
Amlodipine-olmesartan and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, which adds to the potassium-retaining effect of olmesartan. Hyperkalemia is a particular concern in patients with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Amlodipine-olmesartan and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention from angiotensin receptor blockade and drospirenone's aldosterone antagonism.
What to do
Check serum potassium during the first treatment cycle in patients on olmesartan, and avoid use in those with renal impairment. Consider a contraceptive without antimineralocorticoid activity if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Amlodipine-olmesartan with Drospirenone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, which adds to the potassium-retaining effect of olmesartan. Hyperkalemia is a particular concern in patients with renal impairment or other potassium-raising drugs.
How serious is the interaction between Amlodipine-olmesartan and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first treatment cycle in patients on olmesartan, and avoid use in those with renal impairment. Consider a contraceptive without antimineralocorticoid activity if potassium rises.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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