Drug interactions
Amlodipine-olmesartan + Enoxaparin
Severity: Moderate
Amlodipine-olmesartan and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin can suppress aldosterone secretion, and when combined with olmesartan this may lead to hyperkalemia. The risk is greater with renal impairment, diabetes or prolonged heparin therapy.
What this interaction means in plain words
Amlodipine-olmesartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone synthesis, which adds to ARB-induced reduction of potassium excretion.
What to do
Monitor serum potassium and renal function, especially in patients with kidney disease or diabetes or with therapy longer than a few days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Enoxaparin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin can suppress aldosterone secretion, and when combined with olmesartan this may lead to hyperkalemia. The risk is greater with renal impairment, diabetes or prolonged heparin therapy.
How serious is the interaction between Amlodipine-olmesartan and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially in patients with kidney disease or diabetes or with therapy longer than a few days.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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