Drug interactions
Amlodipine-olmesartan + Flurbiprofen
Severity: Moderate
Amlodipine-olmesartan and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can reduce the antihypertensive effect of olmesartan. With an ARB, NSAIDs can also impair kidney function and raise potassium, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Amlodipine-olmesartan and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing ARB effects.
What to do
Monitor blood pressure, creatinine and potassium and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Flurbiprofen?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen can reduce the antihypertensive effect of olmesartan. With an ARB, NSAIDs can also impair kidney function and raise potassium, particularly in elderly or volume-depleted patients.
How serious is the interaction between Amlodipine-olmesartan and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time or choose paracetamol.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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