Drug interactions
Amlodipine-olmesartan + Istradefylline
Severity: Minor
Amlodipine-olmesartan and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline increases exposure to CYP3A4 substrates, which may raise amlodipine levels and cause hypotension or edema. This effect was not seen at 20 mg daily.
What this interaction means in plain words
Amlodipine-olmesartan and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent weak inhibition of CYP3A4 by istradefylline reduces amlodipine clearance.
What to do
Monitor blood pressure and edema if istradefylline 40 mg daily is used, and reduce the amlodipine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Amlodipine-olmesartan with Istradefylline?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily istradefylline increases exposure to CYP3A4 substrates, which may raise amlodipine levels and cause hypotension or edema. This effect was not seen at 20 mg daily.
How serious is the interaction between Amlodipine-olmesartan and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema if istradefylline 40 mg daily is used, and reduce the amlodipine dose if needed.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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