Drug interactions
Enzalutamide + Istradefylline
Severity: Major
Enzalutamide and Istradefylline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers markedly lower istradefylline exposure, which may reduce control of motor fluctuations in Parkinson disease. Labeling advises against this combination.
What this interaction means in plain words
Enzalutamide and Istradefylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Istradefylline belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4, accelerating istradefylline metabolism.
What to do
Avoid concomitant use. Choose an alternative adjunct for Parkinson disease if enzalutamide is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Enzalutamide with Istradefylline?
MediHelp rates the interaction as major. Enzalutamide and Istradefylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inducers markedly lower istradefylline exposure, which may reduce control of motor fluctuations in Parkinson disease. Labeling advises against this combination.
How serious is the interaction between Enzalutamide and Istradefylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. Choose an alternative adjunct for Parkinson disease if enzalutamide is required.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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