Drug interactions
Amlodipine-olmesartan + Ivosidenib
Severity: Moderate
Amlodipine-olmesartan and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower amlodipine concentrations, reducing blood pressure control. The effect develops over days to weeks after starting ivosidenib.
What this interaction means in plain words
Amlodipine-olmesartan and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping ivosidenib. Increase the amlodipine dose or add another antihypertensive if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Ivosidenib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower amlodipine concentrations, reducing blood pressure control. The effect develops over days to weeks after starting ivosidenib.
How serious is the interaction between Amlodipine-olmesartan and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping ivosidenib. Increase the amlodipine dose or add another antihypertensive if control is lost.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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