Drug interactions
Amisulpride + Ivosidenib
Severity: Major
Amisulpride and Ivosidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is labeled for QT prolongation, not shortening, and amisulpride also prolongs the QT interval. Together they can increase the risk of torsades de pointes.
What this interaction means in plain words
Amisulpride and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Avoid if possible. If coadministered, monitor ECG and electrolytes regularly and reduce or hold ivosidenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
- Apalutamide + Ivosidenib Major
Frequently asked questions
Can I take Amisulpride with Ivosidenib?
MediHelp rates the interaction as major. Amisulpride and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib is labeled for QT prolongation, not shortening, and amisulpride also prolongs the QT interval. Together they can increase the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If coadministered, monitor ECG and electrolytes regularly and reduce or hold ivosidenib if QTc becomes markedly prolonged.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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