Drug interactions
Amlodipine-olmesartan + Ketoconazole
Severity: Moderate
Amlodipine-olmesartan and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole is a strong CYP3A4 inhibitor and can raise amlodipine exposure. This may cause excessive vasodilation, hypotension and peripheral edema.
What this interaction means in plain words
Amlodipine-olmesartan and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Ketoconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by ketoconazole.
What to do
Monitor blood pressure and edema when ketoconazole is started or stopped, and lower the amlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Ketoconazole?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole is a strong CYP3A4 inhibitor and can raise amlodipine exposure. This may cause excessive vasodilation, hypotension and peripheral edema.
How serious is the interaction between Amlodipine-olmesartan and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when ketoconazole is started or stopped, and lower the amlodipine dose if hypotension or edema develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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