Drug interactions
Amlodipine-olmesartan + Propranolol
Severity: Minor
Amlodipine-olmesartan and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol adds to the blood pressure lowering of amlodipine and olmesartan, which is often intended but may cause hypotension and bradycardia. Beta-blockers can also slightly raise potassium, adding to ARB effects.
What this interaction means in plain words
Amlodipine-olmesartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from beta blockade, vasodilation and renin-angiotensin blockade; beta blockade modestly impairs cellular potassium uptake.
What to do
Monitor blood pressure, heart rate and periodically potassium and renal function. Titrate doses gradually.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Propranolol?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol adds to the blood pressure lowering of amlodipine and olmesartan, which is often intended but may cause hypotension and bradycardia. Beta-blockers can also slightly raise potassium, adding to ARB effects.
How serious is the interaction between Amlodipine-olmesartan and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and periodically potassium and renal function. Titrate doses gradually.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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