Drug interactions
Amlodipine-olmesartan + Spironolactone
Severity: Major
Amlodipine-olmesartan and Spironolactone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan, an angiotensin receptor blocker, reduces aldosterone-driven potassium excretion, and spironolactone blocks the aldosterone receptor directly. Used together they can cause clinically important hyperkalemia, especially in patients with renal impairment, diabetes or advanced age.
What this interaction means in plain words
Amlodipine-olmesartan and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Additive suppression of the renin-angiotensin-aldosterone system effect on renal potassium excretion.
What to do
Check serum potassium and creatinine before starting and within the first week or two, then at regular intervals. Reduce or stop spironolactone if potassium rises above the accepted range, and avoid potassium supplements.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Spironolactone?
MediHelp rates the interaction as major. Amlodipine-olmesartan and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olmesartan, an angiotensin receptor blocker, reduces aldosterone-driven potassium excretion, and spironolactone blocks the aldosterone receptor directly. Used together they can cause clinically important hyperkalemia, especially in patients with renal impairment, diabetes or advanced age.
How serious is the interaction between Amlodipine-olmesartan and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine before starting and within the first week or two, then at regular intervals. Reduce or stop spironolactone if potassium rises above the accepted range, and avoid potassium supplements.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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