Drug interactions
Amlodipine-olmesartan + Terazosin
Severity: Moderate
Amlodipine-olmesartan and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terazosin, an alpha-1 blocker, adds to blood pressure lowering from amlodipine and olmesartan. Orthostatic hypotension and first-dose syncope can occur.
What this interaction means in plain words
Amlodipine-olmesartan and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade, calcium channel blockade and angiotensin receptor blockade.
What to do
Begin terazosin at a low bedtime dose and monitor standing blood pressure. Reduce other antihypertensives if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Terazosin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terazosin, an alpha-1 blocker, adds to blood pressure lowering from amlodipine and olmesartan. Orthostatic hypotension and first-dose syncope can occur.
How serious is the interaction between Amlodipine-olmesartan and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin terazosin at a low bedtime dose and monitor standing blood pressure. Reduce other antihypertensives if orthostatic symptoms occur.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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