Drug interactions
Lofexidine + Terazosin
Severity: Major
Lofexidine and Terazosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and terazosin adds vasodilation, so together they can cause marked hypotension, bradycardia and syncope. The risk is greatest during opioid withdrawal treatment when patients may also be dehydrated.
What this interaction means in plain words
Lofexidine and Terazosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lofexidine belongs to Central Nervous System; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotension from central alpha-2 agonism plus peripheral alpha-1 blockade.
What to do
Monitor blood pressure and pulse before each dose and advise slow postural changes. Consider reducing or holding terazosin, or adjusting lofexidine, if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Phentolamine + Terazosin Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Terazosin?
MediHelp rates the interaction as major. Lofexidine and Terazosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofexidine lowers blood pressure and heart rate, and terazosin adds vasodilation, so together they can cause marked hypotension, bradycardia and syncope. The risk is greatest during opioid withdrawal treatment when patients may also be dehydrated.
How serious is the interaction between Lofexidine and Terazosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse before each dose and advise slow postural changes. Consider reducing or holding terazosin, or adjusting lofexidine, if symptomatic hypotension or bradycardia develops.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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