Drug interactions
Amlodipine-olmesartan + Tolvaptan
Severity: Moderate
Amlodipine-olmesartan and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan has been associated with increases in serum potassium, and olmesartan reduces aldosterone-mediated potassium excretion. Used together, they may raise the risk of hyperkalemia, particularly in patients with renal impairment or heart failure.
What this interaction means in plain words
Amlodipine-olmesartan and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Additive potassium-raising effects: angiotensin receptor blockade reduces renal potassium excretion while tolvaptan can raise serum potassium.
What to do
Check serum potassium and renal function at baseline and after starting or changing doses. Reassess the combination if potassium rises above the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Tolvaptan?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan has been associated with increases in serum potassium, and olmesartan reduces aldosterone-mediated potassium excretion. Used together, they may raise the risk of hyperkalemia, particularly in patients with renal impairment or heart failure.
How serious is the interaction between Amlodipine-olmesartan and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline and after starting or changing doses. Reassess the combination if potassium rises above the normal range.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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