Drug interactions
Amlodipine-valsartan + Artemether / lumefantrine
Severity: Minor
Amlodipine-valsartan and Artemether / lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether is a weak CYP3A4 inducer and both antimalarial components are CYP3A4 substrates, so amlodipine exposure could be modestly reduced during the short treatment course. The clinical effect is likely small and temporary.
What this interaction means in plain words
Amlodipine-valsartan and Artemether / lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by artemether may increase amlodipine metabolism.
What to do
No routine adjustment is needed; check blood pressure if control appears to worsen during or after the malaria course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Artemether / lumefantrine?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Artemether / lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether is a weak CYP3A4 inducer and both antimalarial components are CYP3A4 substrates, so amlodipine exposure could be modestly reduced during the short treatment course. The clinical effect is likely small and temporary.
How serious is the interaction between Amlodipine-valsartan and Artemether / lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check blood pressure if control appears to worsen during or after the malaria course.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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