Drug reference
amlodipine-valsartan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Amlodipine: Ca channel blocker; inhibits the transmembrane influx of extracellular Ca ions across the membranes of myocardial cells and vascular smooth muscle cells. Valsartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors, causing a lowering in blood pressure; blocks vasoconstrictor and aldosterone-secreting effects
Common side effects
- Nasopharyngitis
- Headache
- Anxiety
- Increased BUN
- Increased potassium
- Peripheral edema
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to valsartan, amlodipine, or excipients Concomitant administration with aliskiren in patients with diabetes mellitus
Known interactions (1)
- amlodipine-valsartan + dantrolene Moderate
Related conditions
Frequently asked questions
What drug class is amlodipine-valsartan?
amlodipine-valsartan belongs to: Cardiovascular.
How does amlodipine-valsartan work?
Amlodipine: Ca channel blocker; inhibits the transmembrane influx of extracellular Ca ions across the membranes of myocardial cells and vascular smooth muscle cells. Valsartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors, causing a lowering in blood pressure; blocks vasoconstrictor and aldosterone-secreting effects
What are the common side effects of amlodipine-valsartan?
Nasopharyngitis, Headache, Anxiety, Increased BUN, Increased potassium, Peripheral edema
Which drugs interact with amlodipine-valsartan?
dantrolene
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