Drug interactions
Amlodipine-valsartan + Aspirin
Severity: Moderate
Amlodipine-valsartan and Aspirin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses, aspirin can blunt the antihypertensive effect of valsartan and reduce renal function, especially in elderly or volume-depleted patients. Low-dose aspirin for cardiovascular prevention has much less effect.
What this interaction means in plain words
Amlodipine-valsartan and Aspirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins by aspirin opposes ARB effects and reduces glomerular filtration.
What to do
Monitor blood pressure, renal function and potassium if higher aspirin doses are used. Ensure adequate hydration; low-dose aspirin generally needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Aspirin?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Aspirin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses, aspirin can blunt the antihypertensive effect of valsartan and reduce renal function, especially in elderly or volume-depleted patients. Low-dose aspirin for cardiovascular prevention has much less effect.
How serious is the interaction between Amlodipine-valsartan and Aspirin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium if higher aspirin doses are used. Ensure adequate hydration; low-dose aspirin generally needs no change.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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