Drug interactions
Amlodipine-valsartan + Carvedilol
Severity: Moderate
Amlodipine-valsartan and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol adds to the blood pressure lowering of amlodipine and valsartan, which can cause hypotension, dizziness or bradycardia. The combination is often used intentionally. Valsartan can modestly raise potassium, but carvedilol is not a clinically important contributor.
What this interaction means in plain words
Amlodipine-valsartan and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive vasodilation and blockade of the sympathetic and renin-angiotensin systems.
What to do
Titrate doses gradually and monitor blood pressure and heart rate. Check for orthostatic symptoms, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Amlodipine-valsartan with Carvedilol?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol adds to the blood pressure lowering of amlodipine and valsartan, which can cause hypotension, dizziness or bradycardia. The combination is often used intentionally. Valsartan can modestly raise potassium, but carvedilol is not a clinically important contributor.
How serious is the interaction between Amlodipine-valsartan and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doses gradually and monitor blood pressure and heart rate. Check for orthostatic symptoms, particularly in older patients.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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