Drug interactions
Amlodipine-valsartan + Deferasirox
Severity: Moderate
Amlodipine-valsartan and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may modestly lower exposure to CYP3A4 substrates, so amlodipine effect may be reduced. Deferasirox can also affect renal function, which matters in patients taking an ARB.
What this interaction means in plain words
Amlodipine-valsartan and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Deferasirox belongs to Miscellaneous.
Why it happens
Deferasirox may induce CYP3A4, increasing amlodipine metabolism, and has nephrotoxic potential that adds to ARB renal risks.
What to do
Monitor blood pressure and renal function; increase the amlodipine dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-valsartan and Deferasirox, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Amlodipine-valsartan with Deferasirox?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may modestly lower exposure to CYP3A4 substrates, so amlodipine effect may be reduced. Deferasirox can also affect renal function, which matters in patients taking an ARB.
How serious is the interaction between Amlodipine-valsartan and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function; increase the amlodipine dose if control worsens.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
