Drug interactions
Amlodipine-valsartan + Dichlorphenamide
Severity: Moderate
Amlodipine-valsartan and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide lowers potassium and causes metabolic acidosis. Amlodipine does not lower potassium, but valsartan tends to raise it, so the net effect varies and electrolyte shifts should be tracked.
What this interaction means in plain words
Amlodipine-valsartan and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Carbonic anhydrase inhibition causes renal bicarbonate and potassium wasting, partly offset by valsartan's potassium retention.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Amlodipine-valsartan with Dichlorphenamide?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide lowers potassium and causes metabolic acidosis. Amlodipine does not lower potassium, but valsartan tends to raise it, so the net effect varies and electrolyte shifts should be tracked.
How serious is the interaction between Amlodipine-valsartan and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically during treatment.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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