Drug interactions
Amlodipine-valsartan + Doxazosin
Severity: Moderate
Amlodipine-valsartan and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxazosin adds to the blood pressure lowering of amlodipine and valsartan and can cause orthostatic hypotension and syncope, particularly with the first dose.
What this interaction means in plain words
Amlodipine-valsartan and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive vasodilation through alpha-1 blockade, calcium channel blockade and angiotensin receptor blockade.
What to do
Start doxazosin at a low dose at bedtime and monitor standing blood pressure. Counsel patients about dizziness on standing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Amlodipine-valsartan with Doxazosin?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxazosin adds to the blood pressure lowering of amlodipine and valsartan and can cause orthostatic hypotension and syncope, particularly with the first dose.
How serious is the interaction between Amlodipine-valsartan and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start doxazosin at a low dose at bedtime and monitor standing blood pressure. Counsel patients about dizziness on standing.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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