Drug interactions
Amlodipine-valsartan + Encorafenib
Severity: Moderate
Amlodipine-valsartan and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can inhibit hepatic OATP uptake and may increase valsartan exposure. It also has mixed inhibitory and inducing effects on CYP3A4, so amlodipine levels may rise or fall unpredictably.
What this interaction means in plain words
Amlodipine-valsartan and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Encorafenib belongs to Oncology.
Why it happens
OATP1B1/1B3 inhibition affecting valsartan and mixed CYP3A4 inhibition and induction affecting amlodipine.
What to do
Monitor blood pressure and adjust the doses of valsartan or amlodipine if hypotension or loss of control occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Amlodipine-valsartan with Encorafenib?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can inhibit hepatic OATP uptake and may increase valsartan exposure. It also has mixed inhibitory and inducing effects on CYP3A4, so amlodipine levels may rise or fall unpredictably.
How serious is the interaction between Amlodipine-valsartan and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the doses of valsartan or amlodipine if hypotension or loss of control occurs.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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