Drug interactions
Amlodipine-valsartan + Fenbufen
Severity: Moderate
Amlodipine-valsartan and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen, an NSAID, can reduce the antihypertensive effect of valsartan and raise the risk of acute kidney injury and hyperkalemia. The risk is higher in elderly, dehydrated or renally impaired patients.
What this interaction means in plain words
Amlodipine-valsartan and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, antagonizing ARB effect and impairing potassium handling.
What to do
Monitor blood pressure, creatinine and potassium, ensure adequate hydration, and use the shortest NSAID course possible or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Fenbufen?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen, an NSAID, can reduce the antihypertensive effect of valsartan and raise the risk of acute kidney injury and hyperkalemia. The risk is higher in elderly, dehydrated or renally impaired patients.
How serious is the interaction between Amlodipine-valsartan and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, ensure adequate hydration, and use the shortest NSAID course possible or an alternative analgesic.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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