Drug interactions
Amlodipine-valsartan + Heparin
Severity: Moderate
Amlodipine-valsartan and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin suppresses aldosterone secretion, and with an angiotensin receptor blocker such as valsartan this can lead to hyperkalemia. The risk increases with renal impairment, diabetes and prolonged heparin use.
What this interaction means in plain words
Amlodipine-valsartan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone synthesis, adding to the potassium-retaining effect of angiotensin receptor blockade.
What to do
Monitor serum potassium, especially if heparin is given for more than a few days or in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Amlodipine-valsartan with Heparin?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin suppresses aldosterone secretion, and with an angiotensin receptor blocker such as valsartan this can lead to hyperkalemia. The risk increases with renal impairment, diabetes and prolonged heparin use.
How serious is the interaction between Amlodipine-valsartan and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially if heparin is given for more than a few days or in patients with renal impairment.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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