Drug interactions
Amlodipine-valsartan + Isradipine
Severity: Moderate
Amlodipine-valsartan and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and isradipine are both dihydropyridine calcium channel blockers, so combining them gives therapeutic duplication. This adds to hypotension, reflex tachycardia, flushing and edema without meaningful additional benefit.
What this interaction means in plain words
Amlodipine-valsartan and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive L-type calcium channel blockade causing vasodilation.
What to do
Avoid combining two dihydropyridines; use a single agent and titrate it. If both are given, monitor blood pressure and heart rate closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Isradipine?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and isradipine are both dihydropyridine calcium channel blockers, so combining them gives therapeutic duplication. This adds to hypotension, reflex tachycardia, flushing and edema without meaningful additional benefit.
How serious is the interaction between Amlodipine-valsartan and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines; use a single agent and titrate it. If both are given, monitor blood pressure and heart rate closely.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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