Drug interactions
Amlodipine-valsartan + Ketorolac intranasal
Severity: Moderate
Amlodipine-valsartan and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac, even by the intranasal route, is systemically absorbed and may blunt the antihypertensive effect of valsartan. In combination, NSAIDs and ARBs can impair renal function, especially in older or volume-depleted patients, and may raise serum potassium.
What this interaction means in plain words
Amlodipine-valsartan and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ARB effects, causing acute kidney injury risk and hyperkalemia.
What to do
Keep the ketorolac course short and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, and avoid the combination in patients with renal impairment or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac, even by the intranasal route, is systemically absorbed and may blunt the antihypertensive effect of valsartan. In combination, NSAIDs and ARBs can impair renal function, especially in older or volume-depleted patients, and may raise serum potassium.
How serious is the interaction between Amlodipine-valsartan and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the ketorolac course short and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, and avoid the combination in patients with renal impairment or volume depletion.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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