Drug interactions
Amlodipine-valsartan + Magnesium supplement
Severity: Minor
Amlodipine-valsartan and Magnesium supplement: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium has mild calcium-antagonist and vasodilating properties and may add to the hypotensive effect of amlodipine. At high parenteral doses, the combination with calcium channel blockers has led to neuromuscular weakness and marked hypotension. With oral supplements, the effect is typically small.
What this interaction means in plain words
Amlodipine-valsartan and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive calcium channel antagonism and vasodilation.
What to do
With oral magnesium, no change is usually needed beyond blood pressure monitoring. With intravenous magnesium, monitor blood pressure and neuromuscular function closely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Magnesium supplement?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Magnesium supplement have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Magnesium has mild calcium-antagonist and vasodilating properties and may add to the hypotensive effect of amlodipine. At high parenteral doses, the combination with calcium channel blockers has led to neuromuscular weakness and marked hypotension. With oral supplements, the effect is typically small.
How serious is the interaction between Amlodipine-valsartan and Magnesium supplement?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With oral magnesium, no change is usually needed beyond blood pressure monitoring. With intravenous magnesium, monitor blood pressure and neuromuscular function closely.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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