Drug interactions
Amlodipine-valsartan + Metformin
Severity: Minor
Amlodipine-valsartan and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can occasionally reduce glucose tolerance slightly, but the effect of amlodipine on glycemic control with metformin is small and inconsistent. No important clinical interaction is generally expected.
What this interaction means in plain words
Amlodipine-valsartan and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Possible minor reduction in insulin sensitivity or secretion with calcium channel blockade; not firmly established.
What to do
No dose adjustment is needed; continue routine glucose monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Metformin
Frequently asked questions
Can I take Amlodipine-valsartan with Metformin?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can occasionally reduce glucose tolerance slightly, but the effect of amlodipine on glycemic control with metformin is small and inconsistent. No important clinical interaction is generally expected.
How serious is the interaction between Amlodipine-valsartan and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; continue routine glucose monitoring.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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