Drug interactions
Amlodipine-valsartan + Parecoxib
Severity: Moderate
Amlodipine-valsartan and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib (via its active metabolite valdecoxib) can blunt the antihypertensive effect of valsartan and reduce renal function, particularly in older or volume-depleted patients. Hyperkalemia and acute kidney injury risk are also increased.
What this interaction means in plain words
Amlodipine-valsartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of COX-2-derived renal prostaglandins reduces renal blood flow and sodium excretion, which antagonizes ARB effect and impairs potassium and renal handling.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the shortest effective parecoxib course or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Parecoxib?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib (via its active metabolite valdecoxib) can blunt the antihypertensive effect of valsartan and reduce renal function, particularly in older or volume-depleted patients. Hyperkalemia and acute kidney injury risk are also increased.
How serious is the interaction between Amlodipine-valsartan and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the shortest effective parecoxib course or choose an alternative analgesic in high-risk patients.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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