Drug interactions
Amlodipine-valsartan + Prazosin
Severity: Moderate
Amlodipine-valsartan and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prazosin is an alpha-1 blocker, and adding it to amlodipine and valsartan increases the antihypertensive effect. This can cause orthostatic hypotension, dizziness and syncope, especially after the first dose.
What this interaction means in plain words
Amlodipine-valsartan and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive vasodilation via alpha-1 adrenergic blockade, calcium channel blockade and angiotensin receptor blockade.
What to do
Start prazosin at a low dose at bedtime and monitor standing blood pressure. Reduce doses if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Amlodipine-valsartan with Prazosin?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prazosin is an alpha-1 blocker, and adding it to amlodipine and valsartan increases the antihypertensive effect. This can cause orthostatic hypotension, dizziness and syncope, especially after the first dose.
How serious is the interaction between Amlodipine-valsartan and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low dose at bedtime and monitor standing blood pressure. Reduce doses if orthostatic symptoms occur.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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