Drug interactions
Amlodipine-valsartan + Salsalate
Severity: Moderate
Amlodipine-valsartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is an NSAID-type salicylate that may weaken the blood pressure lowering effect of valsartan. Together they can worsen renal function and raise potassium, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Amlodipine-valsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces renal perfusion and antagonizes the ARB effect.
What to do
Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated. Use the lowest effective salsalate dose or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Salsalate?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is an NSAID-type salicylate that may weaken the blood pressure lowering effect of valsartan. Together they can worsen renal function and raise potassium, especially in elderly or volume-depleted patients.
How serious is the interaction between Amlodipine-valsartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated. Use the lowest effective salsalate dose or choose an alternative analgesic in high-risk patients.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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