Drug interactions
Amlodipine-valsartan + Saquinavir
Severity: Moderate
Amlodipine-valsartan and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted saquinavir inhibits CYP3A4 and can raise amlodipine concentrations, increasing the risk of hypotension and edema. Valsartan exposure may also rise through inhibition of hepatic uptake transporters.
What this interaction means in plain words
Amlodipine-valsartan and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition raises amlodipine levels, and OATP1B1 inhibition may increase valsartan exposure.
What to do
Monitor blood pressure and edema and reduce the amlodipine dose if needed. Review valsartan tolerability, including renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Saquinavir?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted saquinavir inhibits CYP3A4 and can raise amlodipine concentrations, increasing the risk of hypotension and edema. Valsartan exposure may also rise through inhibition of hepatic uptake transporters.
How serious is the interaction between Amlodipine-valsartan and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and reduce the amlodipine dose if needed. Review valsartan tolerability, including renal function and potassium.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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