Drug interactions
Amlodipine-valsartan + Sulfasalazine
Severity: Minor
Amlodipine-valsartan and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine has been associated with rare renal effects and hyperkalemia, and valsartan can raise potassium and reduce glomerular filtration in susceptible patients. Together they may add to the risk of kidney function decline, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Amlodipine-valsartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effects on renal function and potassium handling; the interaction is not well characterized.
What to do
Check serum creatinine and potassium at baseline and periodically during combined therapy, particularly in elderly or dehydrated patients. Reassess therapy if renal function worsens or potassium rises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Sulfasalazine?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine has been associated with rare renal effects and hyperkalemia, and valsartan can raise potassium and reduce glomerular filtration in susceptible patients. Together they may add to the risk of kidney function decline, especially in elderly or volume-depleted patients.
How serious is the interaction between Amlodipine-valsartan and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum creatinine and potassium at baseline and periodically during combined therapy, particularly in elderly or dehydrated patients. Reassess therapy if renal function worsens or potassium rises.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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