Drug interactions
Amlodipine-valsartan + Synthetic human angiotensin ii
Severity: Moderate
Amlodipine-valsartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Synthetic angiotensin II is a vasopressor given to raise blood pressure in distributive shock, while valsartan blocks the AT1 receptor through which it acts. Valsartan may therefore blunt the pressor response to angiotensin II, and amlodipine adds vasodilation that opposes it.
What this interaction means in plain words
Amlodipine-valsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at the angiotensin II type 1 receptor by valsartan, with additive vasodilation from amlodipine.
What to do
In patients receiving angiotensin II for shock, hold valsartan and amlodipine while hemodynamically unstable. Titrate vasopressor dose to blood pressure response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Frequently asked questions
Can I take Amlodipine-valsartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Synthetic angiotensin II is a vasopressor given to raise blood pressure in distributive shock, while valsartan blocks the AT1 receptor through which it acts. Valsartan may therefore blunt the pressor response to angiotensin II, and amlodipine adds vasodilation that opposes it.
How serious is the interaction between Amlodipine-valsartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients receiving angiotensin II for shock, hold valsartan and amlodipine while hemodynamically unstable. Titrate vasopressor dose to blood pressure response.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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