Drug interactions
Amoxapine + Asenapine
Severity: Moderate
Amoxapine and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause sedation, and amoxapine also has antipsychotic-like dopamine-blocking activity. Using them together increases the risk of arrhythmia, drowsiness and extrapyramidal effects.
What this interaction means in plain words
Amoxapine and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, CNS depression and dopamine receptor blockade.
What to do
Obtain a baseline ECG and monitor the QTc and electrolytes. Watch for sedation and movement disorders and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Amoxapine with Asenapine?
MediHelp rates the interaction as moderate. Amoxapine and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and cause sedation, and amoxapine also has antipsychotic-like dopamine-blocking activity. Using them together increases the risk of arrhythmia, drowsiness and extrapyramidal effects.
How serious is the interaction between Amoxapine and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc and electrolytes. Watch for sedation and movement disorders and use the lowest effective doses.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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