Drug interactions
Amoxapine + Azelastine
Severity: Moderate
Amoxapine and Azelastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating tricyclic-type antidepressant with anticholinergic effects, and azelastine is a sedating antihistamine. Together they may increase drowsiness and impair alertness and coordination.
What this interaction means in plain words
Amoxapine and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from antidepressant and H1-antihistamine activity.
What to do
Counsel on drowsiness and avoid driving until the response is known. Consider a non-sedating antihistamine if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Amoxapine with Azelastine?
MediHelp rates the interaction as moderate. Amoxapine and Azelastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating tricyclic-type antidepressant with anticholinergic effects, and azelastine is a sedating antihistamine. Together they may increase drowsiness and impair alertness and coordination.
How serious is the interaction between Amoxapine and Azelastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving until the response is known. Consider a non-sedating antihistamine if sedation is troublesome.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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