Drug interactions
Amoxapine + Chloral hydrate
Severity: Moderate
Amoxapine and Chloral hydrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant and chloral hydrate is a hypnotic, so combined use can deepen drowsiness and impair psychomotor performance. Additive CNS depression is more likely in older adults and at higher doses.
What this interaction means in plain words
Amoxapine and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects, with amoxapine contributing antihistaminic and anticholinergic sedation.
What to do
Start with reduced doses of the hypnotic and monitor for excessive sedation and confusion. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Amoxapine with Chloral hydrate?
MediHelp rates the interaction as moderate. Amoxapine and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant and chloral hydrate is a hypnotic, so combined use can deepen drowsiness and impair psychomotor performance. Additive CNS depression is more likely in older adults and at higher doses.
How serious is the interaction between Amoxapine and Chloral hydrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses of the hypnotic and monitor for excessive sedation and confusion. Advise patients to avoid driving and alcohol.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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