Drug interactions
Amobarbital + Chloral hydrate
Severity: Major
Amobarbital and Chloral hydrate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedative-hypnotics, so combining them produces additive CNS and respiratory depression. Chloral hydrate metabolites may also alter barbiturate metabolism, making the outcome less predictable.
What this interaction means in plain words
Amobarbital and Chloral hydrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Chloral hydrate belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation, with possible metabolic interplay.
What to do
Avoid combining where possible; if both are required, lower the doses and monitor level of consciousness and respiration. Do not combine with alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Chloral hydrate
Frequently asked questions
Can I take Amobarbital with Chloral hydrate?
MediHelp rates the interaction as major. Amobarbital and Chloral hydrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are sedative-hypnotics, so combining them produces additive CNS and respiratory depression. Chloral hydrate metabolites may also alter barbiturate metabolism, making the outcome less predictable.
How serious is the interaction between Amobarbital and Chloral hydrate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are required, lower the doses and monitor level of consciousness and respiration. Do not combine with alcohol.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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