Drug interactions
Amoxapine + Clonazepam
Severity: Moderate
Amoxapine and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they can cause greater drowsiness, impaired psychomotor performance and cognitive slowing. Amoxapine may also lower the seizure threshold, which can oppose the anticonvulsant effect of clonazepam in epilepsy.
What this interaction means in plain words
Amoxapine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; amoxapine also lowers seizure threshold.
What to do
Start with low doses and advise patients to avoid driving and alcohol until the response is known. Watch for loss of seizure control in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Amoxapine with Clonazepam?
MediHelp rates the interaction as moderate. Amoxapine and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they can cause greater drowsiness, impaired psychomotor performance and cognitive slowing. Amoxapine may also lower the seizure threshold, which can oppose the anticonvulsant effect of clonazepam in epilepsy.
How serious is the interaction between Amoxapine and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and advise patients to avoid driving and alcohol until the response is known. Watch for loss of seizure control in patients with epilepsy.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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