Drug interactions
Alprazolam + Clonazepam
Severity: Major
Alprazolam and Clonazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines taken together produce additive CNS depression, including sedation, impaired coordination, and cognitive and respiratory depression.
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Other interactions of Clonazepam
- Alfentanil + Clonazepam Major
Other interactions of Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
Drug class
- Alprazolam
- Central Nervous System
- Clonazepam
- Central Nervous System
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