Drug interactions
Amoxapine + Cyclobenzaprine
Severity: Major
Amoxapine and Cyclobenzaprine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally a tricyclic and amoxapine is a tricyclic antidepressant, so combined use can increase serotonergic effects and the risk of serotonin syndrome. Additive anticholinergic and sedative effects and cardiac conduction effects are also possible.
What this interaction means in plain words
Amoxapine and Cyclobenzaprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic and anticholinergic activity from two tricyclic-type compounds.
What to do
Avoid combining them where possible and choose a different muscle relaxant. If used together, monitor for agitation, tremor, hyperreflexia, hyperthermia and arrhythmia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Amoxapine with Cyclobenzaprine?
MediHelp rates the interaction as major. Amoxapine and Cyclobenzaprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclobenzaprine is structurally a tricyclic and amoxapine is a tricyclic antidepressant, so combined use can increase serotonergic effects and the risk of serotonin syndrome. Additive anticholinergic and sedative effects and cardiac conduction effects are also possible.
How serious is the interaction between Amoxapine and Cyclobenzaprine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them where possible and choose a different muscle relaxant. If used together, monitor for agitation, tremor, hyperreflexia, hyperthermia and arrhythmia.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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