Drug interactions
Cyclobenzaprine + Selegiline
Severity: Contraindicated
Cyclobenzaprine and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor that becomes nonselective at higher doses, and the transdermal form is used for depression. With cyclobenzaprine, there is a risk of serotonin syndrome and hypertensive crisis. The cyclobenzaprine label contraindicates use with MAO inhibitors.
What this interaction means in plain words
Cyclobenzaprine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition combined with serotonergic and noradrenergic reuptake effects of cyclobenzaprine increases monoamine levels.
What to do
Do not combine, and avoid cyclobenzaprine within 14 days of stopping an MAO inhibitor. Use a non-serotonergic alternative for muscle spasm.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
- Cyclobenzaprine + Tranylcypromine Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Selegiline?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO-B inhibitor that becomes nonselective at higher doses, and the transdermal form is used for depression. With cyclobenzaprine, there is a risk of serotonin syndrome and hypertensive crisis. The cyclobenzaprine label contraindicates use with MAO inhibitors.
How serious is the interaction between Cyclobenzaprine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine, and avoid cyclobenzaprine within 14 days of stopping an MAO inhibitor. Use a non-serotonergic alternative for muscle spasm.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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