Drug interactions
Amoxapine + Cyproheptadine
Severity: Moderate
Amoxapine and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and have anticholinergic activity, so combined use may increase drowsiness, dry mouth, constipation and urinary retention. Older patients may experience confusion.
What this interaction means in plain words
Amoxapine and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects; cyproheptadine's serotonin antagonism may also reduce antidepressant efficacy.
What to do
Monitor sedation, anticholinergic effects and antidepressant response. Reduce doses or choose a non-sedating antihistamine if problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Amoxapine with Cyproheptadine?
MediHelp rates the interaction as moderate. Amoxapine and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and have anticholinergic activity, so combined use may increase drowsiness, dry mouth, constipation and urinary retention. Older patients may experience confusion.
How serious is the interaction between Amoxapine and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, anticholinergic effects and antidepressant response. Reduce doses or choose a non-sedating antihistamine if problems occur.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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