Drug interactions
Belladonna and opium + Cyproheptadine
Severity: Major
Belladonna and opium and Cyproheptadine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium is an opioid and, together with a sedating antihistamine, the risk of profound sedation and respiratory depression is increased. Belladonna and cyproheptadine also both have anticholinergic activity, which raises the risk of urinary retention, constipation and confusion.
What this interaction means in plain words
Belladonna and opium and Cyproheptadine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from the opioid component plus additive anticholinergic effects.
What to do
Avoid combining where possible, or use the lowest effective doses and monitor respiratory rate and level of consciousness. Warn patients against alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
- Brexanolone + Cyproheptadine Major
Frequently asked questions
Can I take Belladonna and opium with Cyproheptadine?
MediHelp rates the interaction as major. Belladonna and opium and Cyproheptadine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium is an opioid and, together with a sedating antihistamine, the risk of profound sedation and respiratory depression is increased. Belladonna and cyproheptadine also both have anticholinergic activity, which raises the risk of urinary retention, constipation and confusion.
How serious is the interaction between Belladonna and opium and Cyproheptadine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or use the lowest effective doses and monitor respiratory rate and level of consciousness. Warn patients against alcohol and other sedatives.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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