Drug interactions
Amoxapine + Desogestrel-ethinyl estradiol
Severity: Minor
Amoxapine and Desogestrel-ethinyl estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives may alter tricyclic antidepressant exposure and response, with reports of increased adverse effects and reduced antidepressant benefit. The evidence is limited.
What this interaction means in plain words
Amoxapine and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of oxidative tricyclic metabolism by estrogens; the mechanism is not firmly established.
What to do
Monitor for anticholinergic and sedative effects and for antidepressant response. Adjust the amoxapine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amoxapine and Desogestrel-ethinyl estradiol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Frequently asked questions
Can I take Amoxapine with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as minor. Amoxapine and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen-containing contraceptives may alter tricyclic antidepressant exposure and response, with reports of increased adverse effects and reduced antidepressant benefit. The evidence is limited.
How serious is the interaction between Amoxapine and Desogestrel-ethinyl estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic and sedative effects and for antidepressant response. Adjust the amoxapine dose if needed.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
