Drug interactions
Amoxapine + Diazepam
Severity: Moderate
Amoxapine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant, and combined with diazepam it can increase drowsiness, psychomotor impairment and falls risk. The effect is most notable in older adults.
What this interaction means in plain words
Amoxapine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects from GABA-A potentiation and antihistaminic and other receptor blockade.
What to do
Use the lowest effective doses and monitor for sedation and impaired coordination. Advise patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Frequently asked questions
Can I take Amoxapine with Diazepam?
MediHelp rates the interaction as moderate. Amoxapine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant, and combined with diazepam it can increase drowsiness, psychomotor impairment and falls risk. The effect is most notable in older adults.
How serious is the interaction between Amoxapine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and impaired coordination. Advise patients to avoid alcohol and driving until the response is known.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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